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SCH 442416
CAS No. 316173-57-6
SCH 442416( —— )
Catalog No. M22962 CAS No. 316173-57-6
SCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 50MG | 426 | In Stock |
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Biological Information
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Product NameSCH 442416
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NoteResearch use only, not for human use.
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Brief DescriptionSCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.
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DescriptionSCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.
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In VitroSCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively).SCH442416 (0.1-10?μM) increases the glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) proteins expression of Müller cells in Group 1?μM.
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In VivoSCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.SCH-442416 (1 μM?2μL; i.v.) increases the GS and GLAST protein expression in rats.SCH442416 (1 μM) significantly attenuates the adenosine-induced dilation (from 15.3 to 5.6 μm).
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Synonyms——
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA2A
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Research Area——
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Indication——
Chemical Information
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CAS Number316173-57-6
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Formula Weight389.42
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Molecular FormulaC20H19N7O2
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESCOc1ccc(cc1)CCCn2c3c(cn2)c4nc(nn4c(n3)N)c5ccco5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kang X , Yu J , Wei Y , et al. The Effect of A 2A Receptor Antagonist (SCH 442416) on the mRNA Expression of Kir 2.1 and Kir 4.1 Channels in Rat Retinal Müller Cells Under Hypoxic Conditions in Vitro[J]. Advances in Clinical and Experimental Medicine, 2013, 22(6):825-829.
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